Van de Ven Double Ends The Toffees' Unbeaten Streak at New Home Ground
The Dutch defender became the initial backline player to score twice in a Premier League match for Tottenham since the Belgian defender in spring 2013.
Match summary
The Spurs defender nods home two times in first half
The home side's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets final goal in dying moments
This loss is Everton's first at Hill Dickinson Stadium
Micky van de Ven found the net on two occasions as Tottenham extended their unbeaten run in away games in the top division and delivered Everton their initial loss at their new home.
Everton were undefeated in their last five matches at their new ground at the dockside location, having left their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from set-pieces in the first half to put their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
The Everton defender believed he had levelled the scores a short while after Van de Ven's first goal, directing a powerful header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a number of chances, while Vicario made a succession of excellent stops to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee stepped in, advising Craig Pawson to review the score on the screen and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team up to third in the Premier League, five points off north London rivals and table-toppers the Gunners.
The Merseyside club stay 14th and sit half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender fulfils duties at each end of pitch
After a uninspiring weekday display in the European competition against the French side, where they managed a only attempts on goal, the manager chose the French striker up front instead of former Toffees player Richarlison.
The summer signing was unable to make much of an impact before being substituted for the substitute after an hour on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with the midfielder heading the ball toward the face of goal for an free the defender to score.
And the captain - stepping up as captain in the Argentine's unavailability - notched his next goal in added time as he outjumped Jordan Pickford to nod in.
The Dutchman was equally outstanding in defensive duties, combining effectively with Kevin Danso as the duo dealt superbly with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a fortress, but it seems the novelty may have worn off somewhat and fans headed to the exits after Sarr's third for Spurs.
The end in Everton's winning streak at home will not be a major concern for David Moyes, but their attacking woes are.
Beto and Thierno Barry - the Toffees' pair of recognised centre-forwards - had scored only one league goal between them before Sunday's outing.
And they were failed to contribute to that poor tally on a wet and gloomy evening on in Liverpool.
The striker's form was epitomized when he chose to overhead kick a clear chance from near the goal, despite having space and opportunity to reposition for a simpler shot that would have challenged Vicario.
Barry, too, was unable to make an impact after replacing the starter in the 65th minute.
It wasn't for a lack of opportunity. Most of Everton's offensive moves came through the winger and Ndiaye, who tirelessly whipped threatening balls into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: Moyes' men travel to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on late October for their next round Carabao Cup match against the Magpies.